Case Western Reserve University
Center for Biomolecular Engineering
Nanoplatforms that carry nucleic acid therapeutics where they need to go, and imaging agents that show clinicians the disease before it spreads.
Formulating nanoparticles at the bench
Cell culture in the biosafety cabinet
Sample preparation
In the laboratory, Wickenden Building
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Nanoparticle delivery animation
Approach
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Our goal is to design and develop simple and smart biomolecules to target specific biological signatures for accurate detection and effective treatment of diseases.
Research
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Research areas
All research
Illustrative render
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Nucleic Acid Therapies
Simple, safe, and smart multifunctional lipids — including the pH-sensitive carrier ECO — that deliver non-coding RNAs and plasmid DNA to their targets.
Read more
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Molecular Imaging
Imaging probes targeted to biomarkers in the tumor microenvironment, for detecting and risk-stratifying aggressive breast and prostate cancer.
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In the news
The Daily · Dec 22, 2021
Dr. Lu elected fellow of National Academy of InventorsThe Daily · May 5, 2021
First clinical trials set for MRI cancer detectionTargeted Oncology · Aug 18, 2019
Novel Molecular MRI Imaging Technique May Lead to Early Detection of Breast Cancer
Recent publications
Metabolic activation using fructose-1, 6-bisphosphate microparticles of non-virally LNP-generated CAR-macrophages induces anti-tumor immune responses
AP Suresh, H Qian, V Uppin, A Thumsi, D Sun, MMCS Jaggarapu, …. Journal of Materials Chemistry B
STAIN-FREE HISTOLOGY AND FLUORESCENCE STAINING OF MICROSCOPY IMAGES USING ARTIFICIAL INTELLIGENCE
L Velayudham, A Ghosh, B Scott, Z Lu, S Brady-Kalnay, D Roy, …. Cytotherapy 28 (5), 102158
Molecular probes and methods of use
ZR Lu, Z Han. US Patent 12,599,684
Archive
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Lab overview
Carried over from the Center's previous site. The clip predates the current group and is kept here for the archive rather than as a current introduction.