Skip to main content
Case Western Reserve UniversityCenter for Biomolecular Engineering

Publications

Peer-reviewed work

269 publications, grouped by year — the list carried over from the Center's previous site, and the dated records from Dr. Lu's Google Scholar profile.

Full list on Google Scholar →

2026

  • Metabolic activation using fructose-1, 6-bisphosphate microparticles of non-virally LNP-generated CAR-macrophages induces anti-tumor immune responses

    AP Suresh, H Qian, V Uppin, A Thumsi, D Sun, MMCS Jaggarapu, …. Journal of Materials Chemistry B

  • STAIN-FREE HISTOLOGY AND FLUORESCENCE STAINING OF MICROSCOPY IMAGES USING ARTIFICIAL INTELLIGENCE

    L Velayudham, A Ghosh, B Scott, Z Lu, S Brady-Kalnay, D Roy, …. Cytotherapy 28 (5), 102158

  • Molecular probes and methods of use

    ZR Lu, Z Han. US Patent 12,599,684

2025

  • MR molecular imaging for monitoring and predicting tumor responses to immunotherapy

    VEA Laney, W Zhao, IM Hwang, E Hampson, J Dong, RC Hall, …. Theranostics 15 (18), 10045

  • Extra Domain B-Fibronectin Targeted Ultrasound Contrast Agents for Pancreatic Cancer Diagnosis

    T Kosmides, P Nittayacharn, S Gao, ZR Lu, A Exner. 2025 IEEE International Ultrasonics Symposium (IUS), 1-4

  • Challenges and opportunities on achieving an adequate delivery efficiency and immunogenicity with peptide-based anticancer vaccines

    Y Wang, D Sun, V Laney, H Wang, LL Wang, ZR Lu. Advanced drug delivery reviews, 115675

  • Compositions and methods for the delivery of nucleic acids

    ZR Lu, AM Vaidya. US Patent 12,378,284

  • Mechanism of pH-sensitive amphiphilic endosomal escape of ionizable lipid nanoparticles for cytosolic nucleic acid delivery: Lu and Sun

    ZR Lu, D Sun. Pharmaceutical research 42 (7), 1065-1077

  • CD40 induces unfolded protein response, upregulation of VEGF, and vascular leakage in diabetic retinopathy

    S Vos, JAC Portillo, A Hubal, R Bapputty, A Pfaff, R Aaron, M Weng, …. Diabetes 74 (5), 798-811

  • Tissue-specific manganese based mri contrast agents

    ZR Lu, JC Qin, R Hall. US Patent App. 18/721,744

2024

  • Diagnosis and monitoring using extradomain-b fibronectin targeted probes

    ZR Lu, A Nadia, R Hall, AM Vaidya, Q Peter. US Patent App. 17/928,764

  • Extradomain b fibronectin targeting peptides and derivatives for cancer imaging and therapy

    S Gao, M Tweedle, ZR Lu. US Patent App. 18/625,695

  • MR Molecular image guided treatment of pancreatic cancer with targeted ECO/mir-200c nanoparticles in immunocompetent mouse tumor models

    V Laney, R Hall, X Yuan, E Hampson, A Halle, G Yeung, KW Bonk, S Apte, …. Pharmaceutical Research 41 (9), 1811-1825

  • Peptide drug conjugates specific to fibronectin isotypes for cancer therapy

    ZR Lu, S Gao. US Patent App. 18/561,384

  • MR molecular imaging of extradomain-B fibronectin for assessing progression and therapy resistance of prostate cancer

    A Vaidya, A Shankardass, M Buford, R Hall, P Qiao, H Wang, S Gao, …. Chemical & Biomedical Imaging 2 (8), 560

  • Intravitreal delivery of PEGylated-ECO plasmid DNA nanoparticles for gene therapy of Stargardt disease

    D Sun, W Sun, SQ Gao, J Lehrer, H Wang, R Hall, ZR Lu. Pharmaceutical research 41 (4), 807-817

  • Assessment of the efficacy of the combination of RNAi of lncRNA DANCR with chemotherapy to treat triple negative breast cancer using magnetic resonance molecular imaging

    C Nicolescu, J Kim, D Sun, ZR Lu. Bioconjugate chemistry 35 (3), 381

2023

2022

2021

2020

2019

2018

2017

  • Synthesis and Assessment of Peptide Gd-DOTA Conjugates Targeting Extradomain B Fibronectin for Magnetic Resonance Molecular Imaging of Prostate Cancer

    Li Y, Han Z, Roelle S, DeSanto A, Sabatelle R, Schur R, Lu ZR

    Mol Pharm, 2017

  • A novel nonviral gene delivery system for treating Leber's congenital amaurosis

    Sun D, Schur RM, Lu ZR

    Ther Deliv, 2017

  • Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis

    Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR

    Mol Ther Nucleic Acids, 2017

  • A Targeted Contrast Agent Specific to an Oncoprotein in Tumor Microenvironment with the Potential for Detection and Risk Stratification of Prostate Cancer with MRI

    Han Z, Li Y, Roelle S, Zhou Z, Liu Y, Sabatelle R, DeSanto A, Yu X, Zhu H, Magi-Galluzzi C, Lu ZR

    Bioconjug Chem, 2017

  • Molecular imaging for precision medicine

    Lu ZR, Minko T

    Adv Drug Deliv Rev, 2017

  • Molecular imaging of the tumor microenviornment

    Zhou Z, Lu ZR

    Adv Drug Deliv Rev, 2017

  • Targeting Fibronectin for Cancer Imaging and Therapy

    Han Z, Lu ZR. J

    Mater Chem B, 2017

  • Improving Radiation Response in Glioblastoma Using ECO Nanoparticle Delivery of siRNA Targeting DNA Damage Repair

    JA Lee, N Ayat, Z Sun, ZR Lu, KA Camphausen. International Journal of Radiation Oncology, Biology, Physics 99 (2), E604

  • Magnetic resonance molecular imaging for non-invasive precision cancer diagnosis

    ZR Lu. Current opinion in biomedical engineering 3, 67-73

  • Design and synthesis of novel pH-responsive multifunctional lipid-like carriers for siRNA delivery

    Z Sun, H Jiang, J Qin, D Sun, ZR Lu. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254

  • Multifunctional ECO/siRNA nanoparticles mediate targeting of long non-coding RNA to inhibit breast cancer proliferation and invasion

    A Vaidya, N Ayat, D Sun, Z Sun, L Hertz, S He, ZR Lu. 2017 Controlled Release Society Annual Meeting

  • NANOPARTICLE-MEDIATED DELIVERY OF MIR-200 TO TRIPLE NEGATIVE BREAST CANCER

    MM Yin, NR Ayat, ZR Lu. The Ohio Journal of Science 117 (1), A13-A13

  • Design and development of a MRI molecular imaging agent that targets EDB-FN for the differential diagnosis of prostate cancer

    Z Han, Y Li, S Roelle, Z Zhou, Y Liu, R Sabatelle, A DeSanto, X Yu, H Zhu, …. DESIGN AND EVALUATION OF NOVEL CONTRAST AGENTS FOR MR MOLECULAR IMAGING OF…

  • MR molecular imaging of triple-negative breast cancer and micrometastases

    Z Han, Z Zhou, ZR Lu. DESIGN AND EVALUATION OF NOVEL CONTRAST AGENTS FOR MR MOLECULAR IMAGING OF…

  • MRI differential diagnosis of breast cancer using a high-relaxivity Gadolinium metallofullerene targeted to extradomain-B fibronectin

    Z Han, X Wu, S Roelle, C Chen, W Schiemann, ZR Lu. DESIGN AND EVALUATION OF NOVEL CONTRAST AGENTS FOR MR MOLECULAR IMAGING OF…

  • Abstract B42: Silencing of DNA repair proteins with ECO/siRNA nanoparticles for the enhancement of radiation response in glioblastoma

    JA Lee, N Ayat, A Tandle, ZR Lu, K Camphausen. Cancer Research 77 (2_Supplement), B42-B42

  • Abstract B45: silencing β3 integrin by targeted ECO/siRNA nanoparticles inhibits EMT and metastasis of triple-negative breast cancer

    JG Parvani, MD Gujrati, MA Mack, WP Schiemann, ZR Lu. Cancer Research 77 (2_Supplement), B45-B45

  • A high-relaxivity extradomain-B fibronectin targeting gadolinium metallofullerene for cancer detection and differential diagnosis in molecular MRI

    Z Han, ZR Lu. Proc. Intl. Soc. Mag. Reson. Med 25, 3582

2016

2015

2014

  • The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM

    A Brett-Morris, BM Wright, Y Seo, V Pasupuleti, J Zhang, J Lu, R Spina, …. Cancer research 74 (23), 6925-6934

  • Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice

    G Yu, X Wu, N Ayat, A Maeda, SQ Gao, M Golczak, K Palczewski, ZR Lu. Biomacromolecules 15 (12), 4570

  • Dendritic nanoglobules with polyhedral oligomeric silsesquioxane core and their biomedical applications

    Z Zhou, ZR Lu. Nanomedicine 9 (15), 2387-2401

  • Multifunctional cationic lipid-based nanoparticles facilitate endosomal escape and reduction-triggered cytosolic siRNA release

    M Gujrati, A Malamas, T Shin, E Jin, Y Sun, ZR Lu. Molecular pharmaceutics 11 (8), 2734-2744

  • Peptide targeted high-resolution molecular imaging of prostate cancer with MRI

    X Wu, G Yu, D Lindner, SM Brady-Kalnay, Q Zhang, ZR Lu. American journal of nuclear medicine and molecular imaging 4 (6), 525

  • Biodegradable iodinated polydisulfides as contrast agents for CT angiography

    E Jin, ZR Lu. Biomaterials 35 (22), 5822-5829

  • Theranostics: Fusion of Therapeutics and Diagnostics: Lu

    ZR Lu. Pharmaceutical research 31 (6), 1355-1357

  • Synthesis and evaluation of a targeted nanoglobular dual-modal imaging agent for MR imaging and image-guided surgery of prostate cancer

    M Tan, Z Ye, D Lindner, SM Brady-Kalnay, ZR Lu. Pharmaceutical research 31 (6), 1469-1476

  • Prophylactic Treatment of Optimized Retinylamine Loaded PLA Particles in a Macular Degeneration Mouse Model

    A Puntel, A Maeda, M Golczak, T Maeda, S Gao, K Palczewski, ZR Lu. Investigative Ophthalmology & Visual Science 55 (13), 6000-6000

  • Synthesis and Evaluation of a Nanoglobular Dendrimer 5-Aminosalicylic Acid Conjugate with a Hydrolyzable Schiff Base Spacer for Treating Retinal Degeneration

    X Wu, G Yu, C Luo, A Maeda, N Zhang, D Sun, Z Zhou, A Puntel, …. ACS nano 8 (1), 153-161

  • Targeted systemic delivery of therapeutic siRNA

    M Gujrati, ZR Lu. Gene therapy of cancer, 47-65

2013

  • Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery

    AS Malamas, M Gujrati, CM Kummitha, R Xu, ZR Lu. Journal of controlled release 171 (3), 296-307

  • Peptide targeted tripod macrocyclic Gd (III) chelates for cancer molecular MRI

    Z Zhou, X Wu, A Kresak, M Griswold, ZR Lu. Biomaterials 34 (31), 7683-7693

  • Molecular MRI of atherosclerotic plaque progression in an ApoE-/-mouse model with a CLT1 peptide targeted macrocyclic Gd (III) chelate

    X Wu, N Balu, W Li, Y Chen, X Shi, CM Kummitha, X Yu, C Yuan, ZR Lu. American Journal of Nuclear Medicine and Molecular Imaging 3 (5), 446

  • MOLECULAR IMAGING OF DRUG DELIVERY

    ZR LU. Advanced Drug Delivery 10, 469

  • MR molecular imaging of prostate cancer with a small molecular CLT1 peptide targeted contrast agent

    X Wu, D Lindner, GP Yu, S Brady-Kalnay, ZR Lu. JoVE (Journal of Visualized Experiments), e50565

  • Multifunctional RNAi Delivery Systems

    CM Kummitha, AS Malamas, ZR Lu. Advanced Delivery and Therapeutic Applications of RNAi, 137-161

  • Molecular magnetic resonance imaging of tumors with a PTP· targeted contrast agent

    SM Burden-Gulley, Z Zhou, SEL Craig, ZR Lu, SM Brady-Kalnay. Translational Oncology 6 (3), 329-337

  • Synthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging

    Z Ye, X Wu, M Tan, J Jesberger, M Grisworld, ZR Lu. Contrast media & molecular imaging 8 (3), 220-228

  • Single cell molecular recognition of migrating and invading tumor cells using a targeted fluorescent probe to receptor PTPmu

    SM Burden-Gulley, MQ Qutaish, KE Sullivant, M Tan, SEL Craig, …. International journal of cancer 132 (7), 1624-1632

  • Gadolinium-based contrast agents for magnetic resonance cancer imaging

    Z Zhou, ZR Lu. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 5 (1), 1-18

  • Molecular MRI of liver fibrosis by a peptide targeted contrast agent in an experimental mouse model

    AM Chow, M Tan, DS Gao, SJ Fan, JS Cheung, K Man, ZR Lu, EX Wu. Investigative radiology 48 (1), 46

  • MR הדמיה המולקולרית של סרטן הערמונית עם חומר ניגוד ממוקד המולקולרי קטן CLT1 פפטיד

    X Wu, D Lindner, GP Yu, S Brady-Kalnay, ZR Lu. Journal of Visualized Experiments (JoVE), e50565

2012

  • Intracellular siRNA delivery with novel spermine based surfactants

    RZ Xu, XL Wang, ZR Lu. Chinese science bulletin 57 (31), 3979-3984

  • Synthesis and evaluation of a peptide targeted small molecular Gd-DOTA monoamide conjugate for MR molecular imaging of prostate cancer

    X Wu, SM Burden-Gulley, GP Yu, M Tan, D Lindner, SM Brady-Kalnay, …. Bioconjugate chemistry 23 (8), 1548

  • MR molecular imaging of prostate cancer with a peptide-targeted contrast agent in a mouse orthotopic prostate cancer model

    M Tan, SM Burden-Gulley, W Li, X Wu, D Lindner, SM Brady-Kalnay, …. Pharmaceutical research 29 (4), 953-960

  • Polydisulfide manganese (II) complexes as non-gadolinium biodegradable macromolecular MRI contrast agents

    Z Ye, EK Jeong, X Wu, M Tan, S Yin, ZR Lu. Journal of Magnetic Resonance Imaging 35 (3), 737-744

  • pH-sensitive siRNA delivery systems

    ZR Lu. Journal of drug delivery science and technology 22 (1), 55-63

2011

  • Ocular Pharmacokinetic Study Using T1 Mapping and Gd-Chelate- Labeled Polymers

    X Shi, X Liu, X Wu, ZR Lu, SK Li, EK Jeong. Pharmaceutical research 28 (12), 3180-3188

  • Peptide targeting imaging agents and methods of use thereof

    ZR Lu, F Ye. US Patent App. 12/919,931

  • Synthesis and evaluation of nanoglobular macrocyclic Mn (II) chelate conjugates as non-gadolinium (III) MRI contrast agents

    M Tan, Z Ye, EK Jeong, X Wu, DL Parker, ZR Lu. Bioconjugate chemistry 22 (5), 931

  • Design, synthesis and evaluation of spermine-based pH-sensitive amphiphilic gene delivery systems: Multifunctional non-viral gene carriers

    RZ Xu, ZR Lu. Science China Chemistry 54 (2), 359-368

  • Integrin targeted MR imaging

    M Tan, ZR Lu. Theranostics 1, 83

  • Molecular MRI of liver fibrosis by Fibrin-Fibronectin targeted contrast agent in an experimental mouse model

    AM Chow, M Tan, DS Gao, SJ Fan, JS Cheung, K Man, ZR Lu, EX Wu. Proc. Intl. Soc. Mag. Reson. Med 19, 453

  • Evaluation of CLT1-(Gd-DTPA) for Cancer MR Molecular Imaging in a Mouse Breast Cancer Model

    F Ye, EK Jeong, D Parker, ZR Lu. Bo pu xue za zhi= Chinese journal of microwave & radio-frequency…

  • 靶向对比剂 CLT1-(Gd-DTPA) 在小鼠乳腺癌磁共振分子成像效果的研究

    F Ye, EK Jeong, D Parker, ZR Lu. 磁共振成像 2, 325-330

2010

  • Use of mri contrast agents for evaluating the treatment of tumors

    ZR Lu, Y Feng, X Wu. US Patent App. 12/738,856

  • Synthesis and evaluation of nanoglobule-cystamine-(Gd-DO3A), a biodegradable nanosized magnetic resonance contrast agent for dynamic contrast-enhanced magnetic resonance urography

    R Xu, TL Kaneshiro, EK Jeong, DL Parker, ZR Lu. International journal of nanomedicine, 707-713

  • New amphiphilic carriers forming pH-sensitive nanoparticles for nucleic acid delivery

    R Xu, XL Wang, ZR Lu. Langmuir 26 (17), 13874-13882

  • An effective targeted nanoglobular manganese (II) chelate conjugate for magnetic resonance molecular imaging of tumor extracellular matrix

    M Tan, X Wu, EK Jeong, Q Chen, DL Parker, ZR Lu. Molecular pharmaceutics 7 (4), 936

  • Polydisulfide-based biodegradable macromolecular magnetic resonance imaging contrast agents

    ZR Lu, X Wu. Israel journal of chemistry 50 (2), 220-232

  • Silencing Expression of Hypoxia Inducible Factor-1 Inhibits Intracranial Glioma Growth: Focus on Nanomolecular System of siRNA Delivery: 971

    RL Jensen, D Gillespie, ZR Lu. Neurosurgery 67 (2), 559

  • Stability and biodistribution of a biodegradable macromolecular MRI contrast agent Gd-DTPA cystamine copolymers (GDCC) in rats

    X Wu, Y Zong, Z Ye, ZR Lu. Pharmaceutical research 27 (7), 1390-1397

  • Dendrimers and methods of making and using thereof

    ZR Lu, T Kaneshiro. US Patent App. 12/377,409

  • Peptide-targeted nanoglobular Gd-DOTA monoamide conjugates for magnetic resonance cancer molecular imaging

    M Tan, X Wu, EK Jeong, Q Chen, ZR Lu. Biomacromolecules 11 (3), 754

  • Molecular imaging of HPMA copolymers: visualizing drug delivery in cell, mouse and man

    ZR Lu. Advanced drug delivery reviews 62 (2), 246-257

  • Non-invasive evaluation of antiangiogenic effect in a mouse tumor model by DCE-MRI with Gd-DTPA cystamine copolymers

    X Wu, EK Jeong, L Emerson, J Hoffman, DL Parker, ZR Lu. Molecular pharmaceutics 7 (1), 41

  • Multifunctional carriers for the delivery of nucleic acids and methods of use thereof

    ZR Lu, XL Wang. US Patent App. 12/443,002

  • Rapid simultaneous acquisition of T1 and T2 mapping images using multishot double spin-echo EPI and automated variations of TR and TE (ms-DSEPI-T12)

    X Liu, Y Feng, ZR Lu, G Morrell, EK Jeong. NMR in Biomedicine: An International Journal Devoted to the Development and…

2009

  • Targeted intracellular codelivery of chemotherapeutics and nucleic acid with a well-defined dendrimer-based nanoglobular carrier

    TL Kaneshiro, ZR Lu. Biomaterials 30 (29), 5660-5666

  • Tumor characterization with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in mice

    X Wu, Y Feng, EK Jeong, L Emerson, ZR Lu. Pharmaceutical research 26 (9), 2202-2208

  • Application of a biodegradable macromolecular contrast agent in dynamic contrast-enhanced MRI for assessing the efficacy of indocyanine green-enhanced photothermal cancer therapy

    Y Feng, L Emerson, EK Jeong, DL Parker, ZR Lu. Journal of Magnetic Resonance Imaging: An Official Journal of the…

  • Image-Guided Photodynamic Cancer Therapy

    ZR Lu, A Vaidya. Pharmaceutical Perspectives of Cancer Therapeutics, 581-599

  • Targeted systemic delivery of a therapeutic siRNA with a multifunctional carrier controls tumor proliferation in mice

    XL Wang, R Xu, X Wu, D Gillespie, R Jensen, ZR Lu. Molecular pharmaceutics 6 (3), 738-746

  • Structural effect on degradability and in vivo contrast enhancement of polydisulfide Gd (III) complexes as biodegradable macromolecular MRI contrast agents

    Y Zong, X Wang, EK Jeong, DL Parker, ZR Lu. Magnetic resonance imaging 27 (4), 503-511

  • Hyaluronic acid containing bioconjugates: targeted delivery of anti-cancer drugs to cancer cells

    Y Luo, GD Prestwich, J Kopecek, ZR Lu. US Patent App. 12/290,879

  • A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery

    XL Wang, R Xu, ZR Lu. Journal of Controlled Release 134 (3), 207-213

  • MRI-Guided Photodynamic Therapy For Cancer

    ZR Lu, A Vaidya, T Ke. US Patent App. 11/792,206

  • A Peptide Targeted Contrast Agent Specific to Fibrin−Fibronectin Complexes for Cancer Molecular Imaging with MRI

    F Ye, EK Jeong, Z Jia, T Yang, D Parker, ZR Lu. Bioconjugate Chemistry 20 (2)

2008

  • Characterization of tumor angiogenesis with dynamic contrast enhanced magnetic resonance imaging and biodegradable macromolecular contrast agents in mice

    Y Feng, EK Jeong, AM Mohs, L Emerson, ZR Lu. Magnetic resonance in medicine: official journal of the Society of Magnetic…

  • Characterization of tumor angiogenesis with dynamic contrast-enhanced MRI and biodegradable macromolecular contrast agents in mice

    Y Feng, EK Jeong, AM Mohs, L Emerson, ZR Lu. Magnetic Resonance in Medicine: An Official Journal of the International…

  • Synthesis and evaluation of globular Gd-DOTA-monoamide conjugates with precisely controlled nanosizes for magnetic resonance angiography

    TL Kaneshiro, EK Jeong, G Morrell, DL Parker, ZR Lu. Biomacromolecules 9 (10)

  • Gadolinium-conjugated TiO2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images

    T Paunesku, T Ke, R Dharmakumar, N Mascheri, A Wu, B Lai, S Vogt, …. Nanomedicine: Nanotechnology, Biology and Medicine 4 (3), 201-207

  • Contrast-enhanced MRI-guided photodynamic cancer therapy with a pegylated bifunctional polymer conjugate

    A Vaidya, Y Sun, Y Feng, L Emerson, EK Jeong, ZR Lu. Pharmaceutical research 25 (9), 2002-2011

  • Gd-DTPA l-Cystine bisisopropyl amide copolymers

    KT Cheng, ZR Lu, T Kaneshiro. Molecular Imaging and Contrast Agent Database (MICAD)[Internet]

  • A multifunctional and reversibly polymerizable carrier for efficient siRNA delivery

    XL Wang, T Nguyen, D Gillespie, R Jensen, ZR Lu. Biomaterials 29 (1), 15-22

2007

  • RGD targeted poly(L-glutamic acid)-cystamine-(Gd-DO3A) conjugate for detecting angiogenesis biomarker ανβ3 integrin with MR T1 mapping

    T Ke, EK Jeong, X Wang, Y Feng, DL Parker, ZR Lu. International journal of nanomedicine 2 (2), 191-199

  • Novel polymerizable surfactants with pH-sensitive amphiphilicity and cell membrane disruption for efficient siRNA delivery

    XL Wang, S Ramusovic, T Nguyen, ZR Lu. Bioconjugate chemistry 18 (6), 2169-2177

  • Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs

    S Sakuma, T Matsumoto, S Yamashita, Y Wang, ZR Lu. Journal of controlled release 123 (3), 195-202

  • Polymer platforms for drug delivery and biomedical imaging

    ZR Lu, F Ye, A Vaidya. Journal of Controlled Release 122 (3), 269-277

  • Synthesis, Characterization, and Gene Delivery of Poly-l-lysine Octa(3-aminopropyl)silsesquioxane Dendrimers: Nanoglobular Drug Carriers with Precisely…

    TL Kaneshiro, X Wang, ZR Lu. Molecular pharmaceutics 4 (5), 759-768

  • In Vivo Evaluation of a PAMAM-Cystamine-(Gd-DO3A) Conjugate as a Biodegradable Macromolecular MRI Contrast Agent

    R Xu, Y Wang, X Wang, EK Jeong, DL Parker, ZR Lu. Experimental Biology and Medicine 232 (8), 1081-1089

  • A novel environment-sensitive biodegradable polydisulfide with protonatable pendants for nucleic acid delivery

    XL Wang, R Jensen, ZR Lu. Journal of controlled release 120 (3), 250-258

  • Modification of Gd-DTPA cystine copolymers with PEG-1000 optimizes pharmacokinetics and tissue retention for magnetic resonance angiography

    AM Mohs, T Nguyen, EK Jeong, Y Feng, L Emerson, Y Zong, DL Parker, …. Magnetic Resonance in Medicine: An Official Journal of the International…

  • Noninvasive Visualization of Pharmacokinetics, Biodistribution and Tumor Targeting of Poly[N-(2-hydroxypropyl)methacrylamide] in Mice Using Contrast…

    Y Wang, F Ye, EK Jeong, Y Sun, DL Parker, ZR Lu. Pharmaceutical research 24 (6), 1208-1216

  • Application of biomedical imaging in drug discovery and development

    ZR Lu. Pharmaceutical Research 24 (6), 1170-1171

  • Gadolinium (III)-based blood-pool contrast agents for magnetic resonance imaging: status and clinical potential

    AM Mohs, ZR Lu. Expert opinion on drug delivery 4 (2), 149-164

  • Biodistribution and pharmacokinetics of colon-specific HPMA copolymer–9-aminocamptothecin conjugate in mice

    SQ Gao, ZR Lu, P Kopečkováÿ, J Kopeček. Journal of controlled release 117 (2), 179-185

  • ISMRM

    X Liu, Y Feng, ZR Lu, EK Jeong. Berlin, Germany

  • Rapid Simultaneous Data acquisition of T1 and T2 Mapping, using Multishot EPI and Automated Variations of TR and TE at 3T

    X Liu, Y Feng, ZR Lu, EK Jeong. International Society for Magnetic Resonance in Medicine, Berlin, Germany

2006

  • Noninvasive visualization of in vivo drug delivery of paramagnetic polymer conjugates with MRI

    ZR Lu, Y Wang, F Ye, A Vaidya, EK Jeong. Nanotechnology for Cancer Therapy, 201-212

  • Polydisulfide Gd (III) chelates as biodegradable macromolecular magnetic resonance imaging contrast agents

    ZR Lu, AM Mohs, Y Zong, Y Feng. International journal of nanomedicine 1 (1), 31-40

  • Contrast-enhanced magnetic resonance angiography with biodegradable (Gd-DTPA)-cystamine copolymers: comparison with MS-325 in a swine model

    TD Nguyen, P Spincemaille, A Vaidya, MR Prince, ZR Lu, Y Wang. Molecular Pharmaceutics 3 (5), 558-565

  • What can you see with imaging in pharmaceutical research?

    ZR Lu. Molecular Pharmaceutics 3 (5), 471-471

  • Contrast enhanced MRI-guided photodynamic therapy for site-specific cancer treatment

    A Vaidya, Y Sun, T Ke, EK Jeong, ZR Lu. Magnetic Resonance in Medicine: An Official Journal of the International…

  • Biodegradable cystamine spacer facilitates the clearance of Gd (III) chelates in poly (glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging

    T Ke, Y Feng, J Guo, DL Parker, ZR Lu. Magnetic resonance imaging 24 (7), 931-940

  • Pharmacokinetics, biodistribution and contrast enhanced MR blood pool imaging of Gd-DTPA cystine copolymers and Gd-DTPA cystine diethyl ester copolymers in a rat model

    Y Feng, Y Zong, T Ke, EK Jeong, DL Parker, ZR Lu. Pharmaceutical research 23 (8), 1736-1742

  • Gd-DTPA l-Cystine Bisamide Copolymers as Novel Biodegradable Macromolecular Contrast Agents for MR Blood Pool Imaging: Kaneshiro et al.

    TL Kaneshiro, T Ke, EK Jeong, DL Parker, ZR Lu. Pharmaceutical research 23 (6), 1285-1294

  • Effect of size and charge on pharmacokinetics and in vivo MRI contrast enhancement of biodegradable polydisulfide Gd (III) complexes

    Y Zong, J Guo, T Ke, AM Mohs, DL Parker, ZR Lu. Journal of controlled release 112 (3), 350-356

  • Colon-specific 9-aminocamptothecin-HPMA copolymer conjugates containing a 1, 6-elimination spacer

    SQ Gao, ZR Lu, B Petri, P Kopečková, J Kopeček. Journal of controlled release 110 (2), 323-331

  • Non-invasive visualization of in vivo drug delivery of poly (L-glutamic acid) using contrast enhanced MRI

    F Ye, T Ke, EK Jeong, X Wang, Y Sun, M Johnson, ZR Lu. Molecular pharmaceutics 3 (5)

  • Rapid Data Acquisition for T1 Mapping, Using Multishot EPI and Automated TR Variation at 3T

    X Liu, Y Feng, T Ke, ZR Lu, KS Li, G Morrell, EK Jeong. ISMRM. Seattle, Washington, USA

2005

  • PEG-g-poly (GdDTPA-co-L-cystine): effect of PEG chain length on in vivo contrast enhancement in MRI

    AM Mohs, Y Zong, J Guo, DL Parker, ZR Lu. Biomacromolecules 6 (4), 2305-2311

  • Pharmacokinetics and tissue retention of (Gd-DTPA)-cystamine copolymers, a biodegradable macromolecular magnetic resonance imaging contrast agent

    X Wang, Y Feng, T Ke, M Schabel, ZR Lu. Pharmaceutical research 22 (4), 596-602

  • Contrast-enhanced MRI with new biodegradable macromolecular Gd (III) complexes in tumor-bearing mice

    Y Zong, X Wang, KC Goodrich, AM Mohs, DL Parker, ZR Lu. Magnetic Resonance in Medicine: An Official Journal of the International…

2004

  • PEG-g-poly (GdDTPA-co-L-cystine): a biodegradable macromolecular blood pool contrast agent for MR imaging

    AM Mohs, X Wang, KC Goodrich, Y Zong, DL Parker, ZR Lu. Bioconjugate chemistry 15 (6), 1424-1430

  • Extracellular biodegradable macromolecular gadolinium (III) complexes for MRI

    ZR Lu, DL Parker, KC Goodrich, X Wang, JG Dalle, HR Buswell. Magnetic Resonance in Medicine: An Official Journal of the International…

2003

  • Poly (l-glutamic acid) Gd (III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging

    ZR Lu, X Wang, DL Parker, KC Goodrich, HR Buswell. Bioconjugate chemistry 14 (4), 715-719

  • Antigen responsive hydrogels based on polymerizable antibody Fab′ fragment

    ZR Lu, P Kopečková, J Kopeček. Macromolecular Bioscience 3 (6), 296-300

  • Polymerizable Fab'antibody fragment targeted photodynamic cancer therapy in nude mice

    ZR Lu, JG Shiah, P Kopeckova, J Kopecek. STP pharma sciences 13 (1), 69-75

2002

  • N-(2-hydroxypropyl) methacrylamide copolymer-9-aminocamptothecin conjugate: colon-specific drug delivery in rats

    S Sakuma, ZR Lu, B Pecharová, P Kopečková, J Kopeček. Journal of bioactive and compatible polymers 17 (5), 305-319

  • Synthesis and characterization of new ointment-like poly (ortho esters)

    J Yu, Z Lu, H Zheng, R Zhuo. European polymer journal 38 (5), 971-975

  • Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates

    Y Luo, NJ Bernshaw, ZR Lu, J Kopecek, GD Prestwich. Pharmaceutical research 19 (4), 396-402

  • Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer–geldanamycin derivative conjugates

    Y Kasuya, ZR Lu, P Kopečková, SE Tabibi, J Kopeček. Pharmaceutical research 19 (2), 115-123

  • Design of novel bioconjugates for targeted drug delivery

    ZR Lu, JG Shiah, S Sakuma, P Kopečková, J Kopeček. Journal of controlled release 78 (1-3), 165-173

2001

  • Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems

    Y Kasuya, ZR Lu, P Kopečková, J Kopeček. Bioorganic & medicinal chemistry letters 11 (16), 2089-2091

  • Biorecognizable HPMA copolymer–drug conjugates for colon-specific delivery of 9-aminocamptothecin

    S Sakuma, ZR Lu, P Kopečková, J Kopeček. Journal of controlled release 75 (3), 365-379

  • Preparation and biological evaluation of polymerizable antibody Fab′ fragment targeted polymeric drug delivery system

    ZR Lu, JG Shiah, P Kopečková, J Kopeček. Journal of controlled release 74 (1-3), 263-268

  • Water-soluble HPMA copolymer–wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo

    L Varticovski, ZR Lu, K Mitchell, I de Aos, J Kopeček. Journal of controlled release 74 (1-3), 275-281

  • Synthesis and characterization of HPMA copolymer–aminopropylgeldanamycin conjugates

    Y Kasuya, ZR Lu, P Kopečková, T Minko, SE Tabibi, J Kopeček. Journal of controlled release 74 (1-3), 203-211

  • Water soluble polymers in tumor targeted delivery

    J Kopeček, P Kopečková, T Minko, ZR Lu, CM Peterson. Journal of controlled release 74 (1-3), 147-158

  • Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers

    ZR Lu, SQ Gao, P Kopečková, J Kopeček. Bioconjugate chemistry 12 (1), 129-133

2000

  • HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action

    J Kopeček, P Kopečková, T Minko, ZR Lu. European journal of pharmaceutics and biopharmaceutics 50 (1), 61-81

  • Synthesis of Bioadhesive Lectin-HPMA Copolymer− Cyclosporin Conjugates

    ZR Lu, SQ Gao, P Kopeckov?, J Kopeček. Bioconjugate Chemistry 11 (1), 3-7

1999

  • Polymerizable Fab′ antibody fragments for targeting of anticancer drugs

    ZR Lu, P Kopečková, J Kopeček. Nature biotechnology 17 (11), 1101-1104

  • Synthesis of semitelechelic poly [N-(2-hydroxypropyl) methacryl-amide] by radical polymerization in the presence of alkyl mercaptans

    ZR Lu, P Kopečková, Z Wu, J Kopeček. Macromolecular Chemistry and Physics 200 (9), 2022-2030

  • In vitro release of 5-fluorouracil with cyclic core dendritic polymer

    RX Zhuo, B Du, ZR Lu. Journal of controlled release 57 (3), 249-257

  • Macromolecular Materials & Engineering-Synthesis of semitelechelic poly (N-(2-hydroxypropyl) methacrylamide) by radical polymerization in the presence of alkyl mercaptans

    ZR Lu, P Kopeckova, Z Wu, J Kopecek. Macromolecular Chemistry and Physics 200 (9), 2022-2030

1998

  • Functionalized Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide] for Protein Modification

    ZR Lu, P Kopečková, Z Wu, J Kopeček. Bioconjugate chemistry 9 (6), 793-804

  • Semitelechelic poly [N-(2-hydroxypropyl) methacrylamide]: Synthesis, characterization and protein modification.

    ZR Lu, P Kopeckova, ZC Wu, J Kopecek. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 216

  • Studies on the preparation and in vitro cytotoxicity of poly (L-aspartic acid) derivatives-cis-platin conjugates

    ZR Lu, JH Yu, RX Zhuo, XL Wang, FH Yang. Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities 19 (5)…

  • Polymerizable Fab′ antibody fragments

    ZR Lu, P Kopeckova, J Kopecek. Proc Intl Symp Controlled Release Bioactive Mater 25, 788-789

  • Solid state NMR study of some substituted silatrane compounds

    XD Zhang, G Zheng, LF Shen, CH Ye, ZR Lu, RX Zhuo. Acta Chimica Sinica 56 (10), 986-989

  • Semitelechelic Poly [N-(2-hydroxypropyl) methacrylamide]: Preparation, Characterization and Protein Modification

    ZR Lu, P Kopeckova, Z Wu, J Lopecek. POLYMER PREPRINTS-AMERICA- 39, 218-219

1997

  • Phosphorylating polycondensation using phosgene as a chain extender

    TY Ke, RX Zhuo, ZR Lu, HQ Feng. European polymer journal 33 (10-12), 1583-1586

  • Synthesis of new ointment-like poly (ortho esters)

    ZP Lu, JH Yu, RX Zhuo. Chinese Chemical Letters 8 (2), 114-116

  • NMR and molecular dynamics study on some substituted silatranes

    XD Zhang, SZ Mao, LF Shen, ZR Lu, RX Zhuo. Acta Chimica Sinica 55 (3), 290-295

  • Synthesis, characterization and relaxivity of amphiphilic chelates of DTPA derivatives with GdIII, YbIII and MnII

    X Zhao, R Zhuo, Z Lu, W Liu. Polyhedron 16 (16), 2755-2759

1996

  • Alkyl Derivatives of Europium (+ 2) and Ytterbium (+ 2). Crystal Structures of Eu [C (SiMe3) 3] 2, Yb [C (SiMe3) 2 (SiMe2CH CH2)] I⊙ OEt2 and Yb [C (SiMe3) 2 (SiMe2OMe)] I⊙ OEt2

    C Eaborn, PB Hitchcock, K Izod, ZR Lu, JD Smith. Organometallics 15 (22), 4783-4790

  • Iodo (methoxydimethylsilyl) bis (trimethylsilyl) methane: a reagent for the preparation of novel organometallic compounds. Crystal structures of Mg {C (SiMe3) 2 (SiMe2OMe)} 2…

    C Eaborn, PB Hitchcock, A Kowalewska, ZR Lu, JD Smith, WA Stańczyk. Journal of organometallic chemistry 521 (1-2), 113-120

  • Novel Chelated Diorganolithate Ion [CH2SiMe2C (SiMe3) 2LiC (SiMe3) 2SiMe2CH2]-and Highly Crowded Chelated Organomercury Compound [CH2SiMe2C (SiMe3) 2HgC (SiMe3) 2SiMe2CH2]

    C Eaborn, ZR Lu, PB Hitchcock, JD Smith. Organometallics 15 (6), 1651-1655

  • Synthesis and proton relaxivity of Gd-EDDS and Gd-THEC

    ZR Lu, RX Zhuo, C Yin, JW Zhou. Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities 17 (1…)

1995

  • Conformational analysis of some substituted silatranyl-carboxylic acids produced by computational study and NMR spectroscopy

    X Zhang, S Mao, L Shen, C Ye, R Zhuo, Z Lu, GA Webb. Journal of Molecular Structure: THEOCHEM 372 (2-3), 249-256

  • SYNTHESES AND CHARACTERIZATION OF METAL-COMPLEXES OF L-LYSINE-N, N, N', N'-TETRAACETIC ACID AND L-LYSINE-N, N, N', N'-TETRAMETHYLENEPHOSPHONIC ACID

    RX ZHOU, ZR Lu, J Wen. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 11 (3), 276-278

  • Synthesis and characterization of (4S)-1-chloroalkylsilatrane-4-carboxylic acids; cruytal structures of (3R, 4S)-1-chloromethyl-3-methylsilatrane-4-carboxylic acid and (3R, 4S…

    ZR Lu, RX Zhuo, LR Shen, XD Zhang, LF Shen. Journal of organometallic chemistry 489 (1-2), C38-C43

1994

  • The Synthesis and Crystal Structure of (4S)-(3-Chloropropyl) Silatrane-4-Carboxylic Acid Monohydrate: A Stable Intermediate in the Hydrolysis of Silatrane

    ZR Lu, RX Zhuo, LR Shen, BS Luo. Main Group Metal Chemistry 17 (5), 377-385

  • Aquahemistry of Titanocene Dichloride and Crystal Structure of Titanocene Bis (salicylate)

    Z Lu, S Gao, Y Zhou, S Wu. Chinese Journal of Applied Chemistry 11 (1), 28-32

1993

  • Synthesis and characterization of (4S)-silatrane-4-carboxylic acids; molecular structure of (3R, 4S)-1-vinyl-3-methylsilatrane-4-carboxylic acid

    RX Zhuo, ZR Lu, J Liao, LF Shen. Journal of organometallic chemistry 446 (1-2), 107-112

1992

  • Aqueous phase synthesis of dicarboxylic derivatives of titanocene

    ZQ Hang, SW Lu, HFG Dalian, ZR Lu, YK Zhou. Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry 22 (7…)

1991

  • Oxidation of alkene with t-butyl hydroperoxide catalysed by copper (II) complexes of tris (2-benzimidazolylmethyl) amine: Model complexes of blue copper proteins

    ZR Lu, YQ Yin, DS Jin. Journal of molecular catalysis 70 (3), 391-397